Harvard University

• In a pharmacokinetic study¹ led by Helen Figge, PharmD, of the Department of Pharmacy, Brigham and Women's Hospital, Dr. Figge and colleagues found extended-release vegetable wax-matrix nicotinic acid exhibited the preferred pharmacokinetic profile to support optimal cholesterol and lipid metabolism.
• In an open label trial² led by J. D. Alderman, MD, of the Cardiovascular Division, Harvard-Thorndike Laboratory, Beth Israel Hospital, Dr. Alderman and colleagues found extended-release vegetable wax-matrix nicotinic acid supplementation for 11 months, on average, not only promoted optimal LDL and HDL cholesterol balance, but also exhibited excellent tolerance with only a 4% dropout rate (4 out of 101 participants).
• In a controlled clinical trial³ led by R. C. Pasternak, MD, Cardiovascular Division, Harvard-Thorndike Laboratory, Beth Israel Hospital, Dr. Pasternak and colleagues found extended-release vegetable wax-matrix nicotinic acidstrong> supplementation to be an effective complementary therapy to support heart health.

Oregon State University, Portland

• In a systematic review⁴ of clinical trials and related studies led by Matthew K. Ito, PharmD, of the OHSU College of Pharmacy, Dr. Ito and colleagues found supplementing with extended-release vegetable wax-matrix nicotinic acid for up to 38 weeks is safe and promotes healthy cholesterol metabolism and blood lipid balance.

Texas Southern University, Houston

• In a comparison study⁵ by Ivy Poon, PharmD, and colleagues at the College of Pharmacy and Health Sciences, typical extended-release niacin supplements were found to exhibit wide variability in their dissolutions rate (a measure nutrient bioavailability). Only extended-release vegetable wax-matrix nicotinic acid exhibited the preferred dissolution profile, underscoring the value of wax-matrix tablet delivery.

University of California, Irvine

• In a controlled clinical trial (proof-of-concept)⁶ led by Joshua Grill, PhD, of the Department of Neurobiology and Behavior, University of California, Irvine, Dr. Grill and colleagues found sustained-release vegetable wax-matrix niacinamide offers potential brain benefits for older adults.

University of Iowa, Iowa City

• In a controlled crossover clinical trial⁷ by Colin Gimblet, PhD, of the Department of Health and Human Physiology, Dr. Gimblet and colleagues found supplementing with sustained-release vegetable wax-matrix resveratrol supports endothelial health and blood vessel function in older adults.

University of Minnesota

• In a 6-week controlled clinical trial⁸ by Joseph Keenan, MD, of the Department of Family Medicine and Department of Family Practice and Community Health, Dr. Keenan found extended-release vegetable wax-matrix nicotinic acid significantly improved blood lipid and cholesterol balance. By contrast, inositol hexanicotinate (“flush-free” niacin) had no impact at all.
• In a 38-week controlled clinical trial⁹, Dr. Keenan and colleagues found long-term use of extended-release vegetable wax-matrix nicotinic acid was safe, well tolerated, and provided therapeutic value for supporting optimal LDL cholesterol metabolism with possible synergy with oat bran.
• In one 8-week controlled, comparison trial¹⁰, Dr. Keenan and colleagues identified the most effective amounts of extended-release vegetable wax-matrix nicotinic acid to support healthy blood cholesterol metabolism with older adults experiencing the most benefits.
• In a 20-week controlled clinical trial¹¹, Dr. Keenan and colleagues found extended-release vegetable wax-matrix nicotinic acid was significantly more effective than a heart-healthy diet alone (American Heart Association Step I Diet) for supporting blood cholesterol balance.

University of Washington, Seattle

• In a cost-comparison study¹² led by C. Daniel Meyers, MD, of the School of Medicine), Dr. Meyers and colleagues compared common brands of niacin supplements. Extended-release vegetable wax-matrix nicotinic acid was found to be a cost-effective therapeutic option for cholesterol and lipid health while the more expensive “no-flush” inositol hexaniacinate products failed to contain any free nicotinic acid.

West Virginia University Medical School

• In a mini-review¹³, Knox Van Dyke, PhD, of the Departments of Biochemistry and Molecular Pharmacology, outlines a multifactorial approach to supporting neurological health, including supplements featuring vegetable wax-matrix tablet technology.
• In a mini-review¹⁴, Knox Van Dyke, PhD, describes the role of oxidative/nitrosative (O/N) stress in metabolism and the potential therapeutic value of supplements featuring vegetable wax-matrix tablet technology to help support metabolic health.

Ministry of Health of the Russian Federation & Affiliates

• In one clinical trial¹⁵ by R.G. Oganov and colleagues, the researchers found supplementing with extended-release vegetable wax-matrix nicotinic acid for one year promotes cardiovascular health and is more effective when combined with exercise.
• In one comparison study¹⁶ by G.S. Mal, the researcher found extended-release vegetable wax-matrix nicotinic acid promoted optimal blood lipid and cholesterol metabolism compared to diet alone.
• In one 6-month controlled, crossover clinical trial¹⁷ by N. G. Kiseleva and colleagues, the researchers found supplementing with extended-release vegetable wax-matrix nicotinic acid promoted healthy LDL and HDL cholesterol metabolism.
• In an open-label clinical trial¹⁸ by O. G. Smolenskaia and colleagues, the researchers found supplementing with extended-release vegetable wax-matrix nicotinic acid for 6 months promoted healthy lipid metabolism and cerebrovascular tone.
• In a pharmacokinetic study¹⁹ by E. A. Ivanovskaya and colleagues, the researchers found tablets of extended-release vegetable wax-matrix nicotinic acid exhibited an intermediate release profile with a peak serum concentration of nicotinic acid achieved at approximately 6 hours and tablet dissolution occurring over 6-8 hours.
• In an open-label clinical trial²⁰ by V. V. Kukharchuk and colleagues, the researchers found supplementing with extended-release vegetable wax-matrix nicotinic acid for up to 2 years supported healthy cholesterol balance and vascular health.
• In an open-label clinical trial²¹ by I. Ozerova and colleagues, the researchers found extended-release wax-matrix nicotinic acid promoted optimal blood lipid balance and cholesterol metabolism, including LDL and HDL cholesterol metabolism.
• In a controlled, crossover clinical trial²² by D. M. Aronov and colleagues, the researchers found supplementing with extended-release vegetable wax-matrix nicotinic acid for 2 months provided therapeutic support for optimal total and LDL cholesterol metabolism with excellent compliance as shown by a low 4.5% dropout rate (4 out of 89 participants), primarily due to skin flushing or digestive upset.
• In a 6-month controlled, crossover clinical trial²³ by R. G. Oganov and colleagues, the researchers found supplementing with extended-release vegetable wax-matrix nicotinic acid was well tolerated and promoted both healthy lipid and lipoprotein (apo-A1 and apo-B) metabolism.