A highly bioavailable form of a naturally-occurring compound that occurs in numerous medicinal plants. These plants have a 3,000-year history of use in Ayurvedic and traditional Chinese medicine to support overall health, including digestive health. But we’ve optimized absorption by making it sustained-release, meaning that you’ll get the benefits of dihydroberberine over the course of 5-7 hours.*

Adults looking to keep blood sugar levels in check and support healthy cholesterol and fat metabolism.*

As a dietary supplement for adults, take one (1) tablet, twice daily with food, or as directed by a healthcare professional.

Dihydroberberine supports overall cardiovascular health and healthy blood vessel function. Its high bioavailability means a lower effective amount is needed, which helps eliminate the digestive upset that can occur with regular berberine.*

Dihydroberberine is a highly-bioavailable form of a powerful antioxidant called berberine.(1)  Sustained-release tablet delivery helps enhance the absorption of dihydroberberine over the course of 5-7 hours. Emerging laboratory research suggests that dihydroberberine may promote glucose balance, lipid metabolism, and cardiovascular health by activating a key biochemical pathway called the activated protein kinase (AMPK) pathway, which plays a major role in glucose balance by modulating transport into peripheral tissues.(2,3) Emerging research also suggests dihydroberberine may even help support weight loss efforts.(4)†

†This product is to be used as part of a healthy low-calorie diet and exercise program.

Vegetable Wax (Rice Bran and/or Carnauba), Isomalt (Vegetable), Stearic Acid (Vegetable), Magnesium Stearate (Vegetable), and Silica.

As with all supplements, consult your healthcare professional prior to use if you have or suspect a medical condition or are taking any medications. Do not use without the advice of your physician if you have diabetes or a related condition as dihydroberberine may lower blood sugar. Do not use if you are pregnant, planning to become pregnant, or nursing. Do not use on children.

Dihydroberberine SR is manufactured in the United States (Oregon) in a state-of-the-art, FDA-registered facility that meets or exceeds current Good Manufacturing Practices (cGMP). Quality control tests are performed at every stage of the manufacturing process from rigorous raw material testing to finished product testing. GlucoVantage® is a registered trademark of Nanjing Nutrabuilding Bio-Tech Co.

1. Feng R, Shou JW, Zhao ZX, et al. Transforming berberine into its intestine-absorbable form by the gut microbiota. Sci Rep. 2015;5:12155. PMID: 26174047.
2. Yin J, Ye J, Jia W. Effects and mechanisms of berberine in diabetes treatment. Review. Acta Pharm Sin B. 2012:2(4):327-334. doi:10.1016/j.apsb.2012.06.003 
3. Cicero AFG, Colletti A, Bajraktari G, et al. Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Arch Med Sci. 2017;13(5):965-1005. PMID: 28883839.
4. Firouzi S, Malekahmadi M, Ghayour-Mobarhan M, Ferns G, Rahimi HR. Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action. Diabetes Metab Syndr Obes. 2018;11:699-705. Review. PMID: 30519065.