Sustained Release Pantethine™ is a dietary supplement that features Pantethine, a highly bioavailable form of pantothenic acid (vitamin B5), formulated for gradual release over several hours. This ensures that your body receives a steady supply of pantethine to support key metabolic functions.

This product is designed for health-conscious adults seeking research-backed cholesterol management, particularly those looking to maintain balanced LDL/HDL levels in the normal range, support cardiovascular function, support liver health, and improve metabolic health through a once-daily sustained-release tablet.*

As a dietary supplement for adults, take one (1) tablet, twice daily, with morning and evening meals, or as directed by your healthcare practitioner. It is normal for this product to have a distinctive botanical aroma.

In addition to supporting heart health and cholesterol balance, Sustained Release Pantethine may also energize cellular metabolism by promoting the conversion of food into energy, support the body's natural detoxification processes, especially in the liver, and aid in maintaining healthy fatty acid metabolism and synthesis.*

Sustained Release Pantethine works at the cellular level, providing a crucial building block for Coenzyme A (CoA), the body’s most active metabolic enzyme. CoA is integral for cellular energy production; it plays a central role in metabolizing carbohydrates, fats, and proteins, converting them into usable energy for the body. CoA is also vital for synthesizing hormones, hemoglobin, and other critical bioactive compounds, supporting various biochemical reactions needed for whole-body health. Lastly, CoA is involved in Phase II detoxification, aiding the body's ability to process and eliminate toxins.(1,2) Concurrently, by enhancing fatty acid metabolism, Pantethine supports the maintenance of healthy cholesterol levels and lipid balance.(3,4,5)*

Vegetable wax (rice bran and/or carnauba), cellulose, stearic acid (vegetable), magnesium stearate (vegetable), silica.

Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking any medications, or are pregnant or nursing. As with all dietary supplements, keep out of reach of children.

Pantethine SR is manufactured in the United States (Oregon) in a state-of-the-art, FDA-registered facility that meets or exceeds current Good Manufacturing Practices (cGMP). Quality control tests are performed at every stage of the manufacturing process from rigorous raw material testing to finished product testing.

1. Trumbo PR. Chapter 25: Pantothenic Acid. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:351-7.
2. Anonymous. Pantethine: Monograph. Altern Med Rev. 2010 Sep;15(3):279-82. Review. https://www.ncbi.nlm.nih.gov/pubmed/21155629.
3. McRae MP. Treatment of hyperlipoproteinemia with pantethine: a review and analysis of efficacy and tolerability. Nutr Res. 2005;25:319-333. https://doi.org/10.1016/j.nutres.2004.12.009
4. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vasc Health Risk Manag. 2014;10:89-100. https://www.ncbi.nlm.nih.gov/pubmed/24600231.
5. Rumberger JA, Napolitano J, Azumano I, Kamiya T, Evans M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. Nutr Res. 2011;31(8):608-15. https://www.ncbi.nlm.nih.gov/pubmed/21925346.