How Niacin Can Slow Down The Aging Process

How Niacin Can Slow Down The Aging Process


Did you know there are 8 kinds of Vitamin B and one of them can slow down the aging process? 

These B complex vitamins are made up of thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), folate (B9) and cobalamin (B12). 

Vitamin B3 —or niacin— is made up of three chemical forms called nicotinic acid, nicotinamide, and nicotinamide riboside that play a big part in your metabolism and aging.

How Niacin Works In Your Body

Nicotinic acid, nicotinamide, and nicotinamide riboside are building blocks of NAD (nicotinamide adenine dinucleotide) which is critical in optimal cell regeneration. Cell regeneration is what keeps your body young. 

The creation of NAD in our body depletes as you age so increasing the intake of niacin as you age is important to maintain healthy energy metabolism and, in turn, cell regeneration.  

In the study, “Niacin Cures Systemic NAD + Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy”, published in early 2020, the patients in the study had adult-onset mitochondrial myopathy, which is a neuromuscular disease caused by damage to the mitochondria.  

The mitochondria is known as the powerhouse of the cell because it is responsible for energy production and the signaling of cell death.  

Life Extension Advocacy Foundation published an article explaining the results of the study.  

The article says, the study “shows that niacin supplements are not simply filtered out by the liver; in fact, they reach the bloodstream in significant amounts to elevate NAD+ levels there.”  

This is great news because nutrients in the bloodstream can be absorbed by the body instead of filtered as wastes by the liver. 

What’s Next?

Niacin is a precursor to NAD which is vital in cell regeneration. NAD creation depletes as you age so you need to increase your intake of niacin as you get older to maintain healthy cell regeneration.  

Although the study showed niacin being absorbed into the bloodstream, your body cannot store vitamin B3 for long periods of time, and excess vitamin B3 not absorbed by the body passes through as waste, so you need to constantly restore these vitamins through food or supplements.  

Here’s a chart from the Food Data for top 10 foods high in vitamin B3 or if you’d like to find more vegetables high in vitamin B3. 

Learn more: 5 Things You Need to Know About Niacin 



Hill, Steve, et al. “Niacin Increases NAD+ Significantly in Human Trial.” Lifespanio, 8 June 2020,
McCulloch, Marsha. “15 Healthy Foods High in B Vitamins.” Healthline, Healthline Media,
“Niacin.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 24 Oct. 2017,
Pirinen E; Auranen M; Khan NA; Brilhante V; Urho N; Pessia A; Hakkarainen A; Kuula J; Heinonen U; Schmidt MS; Haimilahti K; Piirilä P; Lundbom N; Taskinen MR; Brenner C; Velagapudi V; Pietiläinen KH; Suomalainen A; “Niacin Cures Systemic NAD + Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy.” Cell Metabolism, U.S. National Library of Medicine,

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ENDUR-AMIDE® 500mg (nicotinamide, niacinamide)

ENDUR-AMIDE® 500mg (nicotinamide, niacinamide)

Sustained Release

From $17.99

Our bodies use niacinamide (amide form of niacin) to produce nicotinamide adenine dinucleotide (NAD), a critical co-enzyme in every cell that supports healthy aging, including healthy DNA repair and cell division.


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  • Provides a gradual, measured release of niacinamide over 5 to 7 hours

Product Description

ENDUR-AMIDE® 500mg Sustained Release Niacinamide is ideal for adults who want whole body nutritional support with targeted benefits for healthy aging.*

ENDUR-AMIDE® features niacinamide (also known nicotinamide) in a proprietary vegetable-based wax matrix. The wax-matrix delivery system ensures a gradual, measured release of niacinamide over a 5 to 7 hour period. oh This unique sustained-release profile has made ENDUR-AMIDE® the preferred form of niacinamide among clinical researchers.*

ENDUR-AMIDE® niacinamide is an amide form of nicotinic acid (niacin). The two forms share many of the same functions in the body, but nicotinic acid is the doctor-preferred form to support heart health and cholesterol balance. By contrast, niacinamide is the preferred form for skin health, healthy cell division, and other healthy aging benefits.*

ENDUR-AMIDE® helps activate biochemical pathways responsible for cellular energy production and plays a central role in helping to maintain healthy DNA: the genetic blueprint found in all cells. It helps to activate hundreds of enzymes involved in the metabolism of carbohydrates, fatty acids, and amino acids as well as in the synthesis of fatty acids, steroids, hormones and numerous other bioactive compounds.*

ENDUR-AMIDE® works by providing a biochemical building block for your body to produce nicotinamide adenine dinucleotide (NAD), the active form of niacin. In this form, niacinamide not only plays a role in cellular metabolism and DNA repair, but also helps combat oxidative stress and promotes a healthy inflammatory response. Neurons are particularly sensitive to NAD balance. By influencing levels of NAD within neurons, nicotinamide may play a key role in promoting healthy neuron function.*

ENDUR-AMIDE® tablets are available in two strengths: 500 mg and 750 mg.


  • Easy-to-swallow tablets
  • No salt, sugar, starch, preservatives, artificial colors or flavorings
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Frequently Asked Questions

What can you expect?

ENDUR-AMIDE® is a unique dietary supplement for men and women to support skin health, healthy aging and whole body health.* 

How does it work?

In the body, each tablet dissolves slowly over 5 to 7 hours for a controlled release of niacinamide.

How do you take it?

As a dietary supplement for adults, take one (1) to three (3) tablets daily with food or drink, or as directed by your healthcare professional. Do not exceed recommended dose without consulting a physician. It is normal for this product to have a distinctive botanical aroma.

Are there any precautions?

Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking any medications, or are nursing or pregnant. As with all dietary supplements, keep out of reach of children.

What product quality control tests are performed?

ENDUR-AMIDE® is manufactured in the United States (Oregon) in a state-of-the-art, FDA-registered facility that meets or exceeds current Good Manufacturing Practices (cGMP). Quality control tests are performed at every stage of the manufacturing process from rigorous raw material testing to finished product testing.

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