Most people think about longevity in terms of how long they live. But the real measure is how well they live — how strong, sharp, and energetic they stay as they age.

For adults over 45, the signs of metabolic slowdown are familiar: weight gain, low energy, brain fog, or issues with cholesterol metabolism or glucose balance. These aren’t isolated issues — they’re all connected to the same root system: metabolic health.

It’s the quiet engine behind cardiovascular function, cognitive clarity, sustained energy, and healthy aging. Yet most people don’t think about metabolism until it starts to decline.

Supporting metabolic health proactively may be one of the smartest moves for long-term vitality — and today’s science is making it easier to do just that.

What Is Metabolic Health?

Metabolism is more than just how fast you burn calories. It’s the foundation for nearly every major system in the body.

Healthy metabolism supports:

• Glucose balance and insulin sensitivity
  

• Cholesterol and lipid processing
  

• Mitochondrial energy production
  

• Healthy inflammatory response and cellular resilience
  

When your metabolic system is working well, you feel it — energy is steady, thinking is clear, and your cardiovascular system stays balanced.

When it begins to struggle, the effects ripple across the board: slower recovery, increased belly fat, fatigue, and shifting blood markers. These are signals — not inevitabilities.

Why Metabolic Efficiency Declines After 45

Beginning in your mid-40s, several age-related changes can affect optimal metabolic balance:

• Lower muscle mass, which reduces baseline metabolic activity
  

• Increased oxidative stress, which affects the body’s natural inflammatory response
  

• Hormonal shifts that affect glucose handling and fat storage
  

• Mitochondrial function begins to decline, reducing energy output
  

Even with good habits, these biological shifts can cause energy to dip and weight to rise. It’s not about “boosting” metabolism — it’s about supporting its core functions through smarter, science-informed strategies.

How to Support Metabolic Health Naturally

Maintaining metabolic efficiency starts with a few key habits:

• Whole-food nutrition that supports blood sugar and lipid balance
  

• Regular physical activity, especially resistance training
  

• Restorative sleep to enhance insulin sensitivity
  

• Stress management to keep cortisol under control
  

Alongside lifestyle changes, certain nutrients have been shown to help:

• Promote healthy glucose metabolism
  

• Support insulin sensitivity
  

• Maintain cardiovascular and mitochondrial function
  

One of the most promising compounds in this space is dihydroberberine — a next-generation form of a clinically studied ingredient used in ancient Chinese herbal medicinal practices that helps support metabolic wellness.

Dihydroberberine: A Smarter Way to Support Metabolic Function

Berberine is well-researched for its ability to support healthy glucose balance and lipid metabolism, but standard forms have limitations:

• Low bioavailability (poor absorption)
  

• Gastrointestinal discomfort in some users
  

• Short activity window in the body
  

Dihydroberberine is a more advanced form — and a smarter solution. Berberine’s positive charge slows absorption because intestinal cells favor neutral compounds like dihydroberberine, and carrier proteins pump much of it back into the gut. Dihydroberberine bypasses this bottleneck by being readily absorbed and entering the bloodstream more effectively. Once inside, it easily converts to berberine to deliver its full metabolic benefits.

Why It Works:

• Up to 5x more bioavailable than standard berberine
  

• Supports activation of AMPK, a key metabolic switch involved in fat and glucose metabolism
  

• Helps maintain healthy blood sugar levels in the normal range, cholesterol balance, lipid metabolism, and mitochondrial energy output
  

For adults looking to support energy, cardiovascular function, and a healthy weight as they age, dihydroberberine offers a science-backed, well-tolerated option.

A Smarter Formulation: ENDUR™ Dihydroberberine SR

ENDUR™ Dihydroberberine SR takes highly bioavailable dihydroberberine to the next level. First, it features SmartMatrix™ tablet technology that results in precision delivery of this bioactive powerhouse to the intestine where it is most efficiently absorbed. Next the Secure Release™ tablet ensures a slow, steady release of dihydroberberine over 5 to 7 hours to promote optimal absorption. The result is targeted metabolic support with the convenience of clean, easy-to-swallow-tablets free of unnecessary or undesirable additives.*

Why Synergy and Delivery Matter More as You Age

Metabolic health isn’t a one-pathway issue — and it can’t be addressed with a single ingredient. As your body ages, how nutrients are delivered, absorbed, and interact becomes just as important as what you take.

That’s where our SmartMatrix™ technology sets Endur™ products apart.

What Is SmartMatrix™ — and Why Does It Matter?

SmartMatrix™ technology is a proprietary tableting process developed through decades of biochemical research. Originally created by biochemist and formulation pioneer Terry Hammerschmidt in the 1970s, this unique tableting method was designed to solve a simple but critical problem: how to get nutrients where they’re actually needed — and keep them working longer.

Unlike coated pills or capsules that rely on synthetic polymers, SmartMatrix™ tablets are made using a vegetable wax matrix core. Nutrients are encased directly into the core, not simply covered in a coating. This structure allows the tablet to enter the intestine where it slowly dissolves, releasing nutrients gradually over several hours — much like the way food is digested.

The result is optimal nutrient absorption to target what matters most — without the spikes, crashes, or unwanted side effects linked to rapid-release supplements.

With SmartMatrix™ technology, tablets release up to 99% of the active ingredients, helping your body get more of what it needs — where and when it needs it.

It’s a smarter way to support metabolic health, energy, and overall wellness — especially as your body’s needs evolve with age.

This approach helps ensure that what goes into your supplement is primed for optimal absorption and retention in the tissue where it’s needed.

What You Can Do Today

If you’re over 45 and starting to feel the effects of metabolic slowdown, now is the time to take action. You can:

• Talk to your healthcare provider about your metabolic health
  

• Move consistently, build strength, and prioritize quality sleep
  

• Reduce added sugars and focus on nutrient-dense, high-fiber meals
  

• Supplement with intention with a trusted brand, science-backed formulas, full transparency labels

Your Metabolism Drives More Than You Think

Metabolic health may not be a longevity multiplier, but it’s just about the quickest path to feeling your best every day. 

Your body changes with age — but with smart support, you don’t have to lose your edge.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.